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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| Riley O'Brien | 2020-2020 | .000 | 0 | 0 | 6 | 5 | 0 | 4.28 | 110 |
| Darren O'Day | 2020-2020 | .000 | 0 | 0 | 4 | 1 | 0 | 6.08 | 49 |
| Brian O'Grady | 2020-2020 | .167 | 1 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| Tyler O'Neill | 2020-2020 | .195 | 12 | 21 | 0 | 0 | 0 | 9.00 | 1 |
| Scott Oberg | 2020-2020 | .000 | 0 | 0 | 6 | 6 | 1 | 3.05 | 83 |
| Rougned Odor | 2020-2020 | .193 | 11 | 40 | 0 | 0 | 0 | 0.00 | 0 |
| Jake Odorizzi | 2020-2020 | .000 | 0 | 0 | 7 | 11 | 0 | 6.03 | 171 |
| Shohei Ohtani | 2020-2020 | .295 | 39 | 92 | 11 | 9 | 0 | 4.09 | 221 |
| Chris Okey | 2020-2020 | .438 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Edward Olivares | 2020-2020 | .333 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Matt Olson | 2020-2020 | .292 | 42 | 113 | 0 | 0 | 0 | 0.00 | 0 |
| Rafael Ortega | 2020-2020 | .179 | 3 | 7 | 0 | 0 | 0 | 0.00 | 0 |
| Jose Osuna | 2020-2020 | .228 | 7 | 24 | 0 | 0 | 0 | 0.00 | 0 |
| Roberto Osuna | 2020-2020 | .000 | 0 | 0 | 6 | 2 | 23 | 3.09 | 82 |
| Adam Ottavino | 2020-2020 | .000 | 0 | 0 | 2 | 5 | 1 | 6.34 | 129 |
| Marcell Ozuna | 2020-2020 | .288 | 29 | 93 | 0 | 0 | 0 | 0.00 | 0 |
