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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| O'Brien, Riley | SP | Albuquerque Isotopes | 26 | 02/06/1995 | Shoreline | USA | Right | Right | 6' 4" | 180 lbs | $555,000 |
| O'Day, Darren | RP | Free Agent | 38 | 10/22/1982 | Jacksonville | USA | Right | Right | 6' 4" | 215 lbs | - |
| O'Neill, Tyler | LF | Milwaukee Milkshakes | 26 | 06/22/1995 | Vancouver | CAN | Right | Right | 5' 11" | 205 lbs | $582,750 |
| Ober, Bailey | SP | Brooklyn Sycamores | 26 | 07/12/1995 | Huntersville | USA | Right | Right | 6' 9" | 250 lbs | $555,000 |
| Oberg, Scott | RP | Indianapolis Gearheads | 31 | 03/13/1990 | Tewksbury | USA | Right | Right | 6' 2" | 200 lbs | $1,430,000 |
| Obeso, Tony | RF | Rochester Squirrel Cats | 18 | 04/20/2003 | Puerto Plata | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Odor, Rougned | 2B | Indianapolis Gearheads | 27 | 02/03/1994 | Maracaibo | VEN | Left | Right | 5' 11" | 200 lbs | $555,000 |
| Odorizzi, Jake | SP | Mesa Barracudas | 31 | 03/27/1990 | Breese | USA | Right | Right | 6' 2" | 195 lbs | $12,500,000 |
| Ohtani, Shohei | DH | Nashville Nightcaps | 27 | 07/05/1994 | Iwate | JPN | Left | Right | 6' 4" | 205 lbs | $5,000,000 |
| Okey, Chris | C | Albuquerque Isotopes | 26 | 12/29/1994 | Mt. Dora | USA | Right | Right | 5' 11" | 200 lbs | $555,000 |
| Oliva, Jared | CF | New York Yaks | 25 | 11/27/1995 | Santa Clarita | USA | Right | Right | 6' 2" | 200 lbs | $555,000 |
| Olivares, Edward | RF | Seattle Fury | 25 | 03/06/1996 | Caracas | VEN | Right | Right | 6' 2" | 190 lbs | $555,000 |
| Olivio, Guillermo | 3B | Phoenix Volcanoes | 17 | 09/02/2004 | Santo Domingo | DOM | Right | Right | 6' 2" | 190 lbs | - |
| Olmos, Dario | C | San Diego Matadors | 16 | 05/23/2005 | San Juan de la Maguana | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Olmos, Omar | RF | Baltimore Archers | 16 | 07/10/2005 | Panama | PAN | Right | Right | 6' 6" | 200 lbs | - |
| Olson, Matt | 1B | Brooklyn Sycamores | 27 | 03/29/1994 | Atlanta | USA | Left | Right | 6' 5" | 225 lbs | $6,700,000 |
| Olvera, Jose | LF | New Orleans Simules | 17 | 09/03/2004 | Pimentel | DOM | Left | Right | 6' 3" | 195 lbs | - |
| Ornelas, Jerry | SP | San Diego Matadors | 17 | 11/03/2003 | Palo Negro | VEN | Left | Left | 6' 2" | 175 lbs | - |
| Orosco, Ismael | SP | Houston Musketeers | 17 | 08/25/2004 | Santo Domingo | DOM | Left | Right | 5' 11" | 160 lbs | - |
| Orozco, John | SP | New Orleans Simules | 17 | 03/16/2004 | Santa Bárbara del Zulia | VEN | Right | Right | 6' 2" | 175 lbs | - |
| Orozco, Luis | CF | Tucson Dust Devils | 23 | 06/10/1998 | Ponce | PUR | Left | Left | 6' 3" | 190 lbs | $555,000 |
| Orozco, Manny | SP | Phoenix Volcanoes | 17 | 08/06/2004 | Guasdualito | VEN | Right | Right | 5' 9" | 155 lbs | - |
| Ortega, Jose | 2B | Austin Murder Hornets | 18 | 09/08/2003 | Cambita Garabitos | DOM | Right | Right | 6' 4" | 185 lbs | - |
| Ortega, Ruben | SP | Philadelphia Phalanx | 17 | 12/15/2003 | Bajos de Haina | DOM | Right | Right | 6' 5" | 195 lbs | - |
| Ortiz, Ricky | SP | Denver Moose | 17 | 08/24/2004 | Santo Domingo | DOM | Right | Right | 6' 1" | 175 lbs | - |
| Ortiz, Tony | SP | New York Yaks | 18 | 03/29/2003 | Maracaibo | VEN | Left | Left | 6' 7" | 195 lbs | - |
| Osuna, Jose | 1B | Denver Moose | 28 | 12/12/1992 | Trujillo | VEN | Right | Right | 6' 2" | 240 lbs | $555,000 |
| Osuna, Roberto | CL | Oklahoma City Trash Pandas | 26 | 02/07/1995 | Juan José Ríos | MEX | Right | Right | 6' 2" | 215 lbs | $7,000,000 |
| Otero, Mario | RF | New York Yaks | 17 | 10/09/2004 | Santo Domingo | DOM | Left | Left | 6' 2" | 190 lbs | - |
| Ottavino, Adam | RP | Free Agent | 35 | 11/22/1985 | New York | USA | Switch | Right | 6' 5" | 215 lbs | - |
| Oviedo, Jose | SP | Austin Murder Hornets | 17 | 04/07/2004 | Santo Domingo | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Ozuna, Marcell | LF | Mesa Barracudas | 30 | 11/12/1990 | Santo Domingo | DOM | Right | Right | 6' 1" | 220 lbs | $13,500,000 |
