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| Thursday, October 14th, 2021 |
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| LF Mark Zagunis retired from professional baseball. |
| Hitting Coach Manny Villacis leaves the team, his contract was not renewed. |
| Monday, September 27th, 2021 |
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| Activated 2B Nick Simpson from the injured list. |
| Activated SP Jayden Murray from the injured list. |
| Monday, September 6th, 2021 |
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| Placed SP Jayden Murray on the 7-day injured list, retroactive to 09/05/2021. |
| Wednesday, September 1st, 2021 |
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| Activated SP JP Sears from the injured list. |
| Wednesday, August 25th, 2021 |
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| Placed SP JP Sears on the 7-day injured list, retroactive to 08/24/2021. |
| Tuesday, August 3rd, 2021 |
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| Placed 2B Nick Simpson on the 7-day injured list, retroactive to 08/02/2021. |
| Saturday, July 31st, 2021 |
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| Activated SP Conner Greene from the injured list. |
| Tuesday, July 20th, 2021 |
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| Activated SP Sam Hentges from the injured list. |
| Activated RP Ty Tice from the injured list. |
| Friday, July 9th, 2021 |
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| Activated RP Harold Cortijo from the injured list. |
| Tuesday, June 22nd, 2021 |
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| Placed RP Ty Tice on the 7-day injured list, retroactive to 06/21/2021. |
| Tuesday, June 15th, 2021 |
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| Placed SP Conner Greene on the 7-day injured list, retroactive to 06/14/2021. |
| Friday, June 11th, 2021 |
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| Activated RF Ibandel Isabel from the injured list. |
| Saturday, May 29th, 2021 |
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| Placed RF Ibandel Isabel on the 7-day injured list, retroactive to 05/28/2021. |
| Monday, May 24th, 2021 |
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| Activated RP Danny Hultzen from the injured list. |
| Friday, May 14th, 2021 |
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| Placed RP Harold Cortijo on the 7-day injured list, retroactive to 05/13/2021. |
| Wednesday, May 12th, 2021 |
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| Activated RP Austin Cox from the injured list. |
| Wednesday, May 5th, 2021 |
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| Placed RP Austin Cox on the 7-day injured list, retroactive to 05/04/2021. |
| Wednesday, April 28th, 2021 |
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| Placed RP Danny Hultzen on the 7-day injured list, retroactive to 04/27/2021. |
| Sunday, March 7th, 2021 |
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| Placed SP Sam Hentges on the 7-day injured list, retroactive to 08/31/2020. |
